بررسی مقایسه ای سطح سرمی آدیپونکتین قبل و بعد از پیوند کلیه

  Background: Serum adiponectin has been proposed to have role in coronary disease and cardiovascular events in general population. Concentration of this protein increases in renal insufficiency but the role of kidney in adiponectin elimination is undetermined. The aim of this study WAS to compare the concentration of serum adiponectin before and after kidney transplantation and its association with renal function after transplant.   Methods : In this cross sectional study, we enrolled candidates with End Stage Renal Disease (ESRD) along with 40 healthy persons for control group. These groups were matched for both age and gender. Concentration of adiponectin was measured with Elisa one day before kidney transplantation (after dialysis) and 14 days after kidney transplantation with stable kidney function.   Results: There was a positive relation between GFR and HDL with adiponectin changes. There was a positive relation between creatinine (p=0.001) and LDL (p= 0.005) distribution between two groups after transplantation. There was a positive relation between GFR, creatinine (p= 0.001) and HDL (p= 0.018) before and after transplantation. Concentration of adiponectin in ESRD patients was higher than among healthy controls. After transplantation concentration of adiponectin was higher than healthy controls. Comparison of before and after transplantation, concentration of adiponectin was lower after transplantation but was higher than controls.   Conclusions: Kidney function is proposed to be an effective factor in adiponectin concentration.